tetrabenazine

Ligand id: 4834

Name: tetrabenazine

Abbreviated name: TBZ

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 38.77
Molecular weight 317.2
XLogP 2.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Tetrabenazine has been used in the past as an antipsychotic, but is now used primarily in the symptomatic treatment of hyperkinetic disorders including chorea in Huntington's disease, Tourette syndrome and tardive dyskinesia.
Mechanism Of Action and Pharmacodynamic Effects
Reversibly inhibits the vesicular monoamine transporter 2 (SLC18A2). This decreases the amount of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine stored in presynaptic vesicles, and results in increased metabolism of the extra-vesicular neurotransmitters by monoamine oxidase. This leads to an net reduction in catecholamine-driven neuro-activity. The principal action is believed to be depletion of presynaptic dopamine levels.
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