brain natriuretic peptide

Ligand id: 4890

Name: brain natriuretic peptide

Abbreviated name: BNP

Species: Human

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Summary of Clinical Use
Nesiritide is used to relaxe and dilate blood vessels, lowering blood pressure. The drug is also used to improve breathing in patients with congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
In its natural form, the endogenous peptide BNP binds to the guanylate cyclase receptor in vascular smooth muscle and endothelial cells. This leads to the relaxation of smooth muscle through increasing intracellular concentrations of guanosine 3'5'-cyclic monophosphate. This in turn leads to the dilation of veins and arteries.