Ligand id: 4921

Name: erythropoietin

Species: Human

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Summary of Clinical Use
Epoetin alfa is used to treat anemia caused by chemotherapy, chronic kidney disease, or as a result of taking zidovudine to treat HIV. It may also be used before and after surgical procedures where blood loss would indicate the need for red blood cell transfusion.
Mechanism Of Action and Pharmacodynamic Effects
Binding of erythropoietin to the erythropoietin receptor activates the JAK-STAT signaling pathway, which in turn results in the activation of transcription factors that control red blood cell formation.