Ligand id: 493

Name: silodosin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 14
Topological polar surface area 97.05
Molecular weight 495.23
XLogP 3.63
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to improve urinary flow in patients with benign prostatic hyperplasia (BPH).
Mechanism Of Action and Pharmacodynamic Effects
Silodosin is an antagonist at the α1A-adrenoceptor [1]. The drug acts to relax the muscles in the prostate and bladder neck, making it easier to urinate.
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