(-)-noradrenaline

Ligand id: 505

Name: (-)-noradrenaline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 86.71
Molecular weight 169.07
XLogP -0.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of vasodilatory shock states such as septic shock and neurogenic shock. Also used in the treatment of critical hypotension as a vasopressor medication.
Mechanism Of Action and Pharmacodynamic Effects
Agonism of alpha-1 and alpha-2 adrenergic receptors leads to peripheral vasoconstriction. Activity at beta-adrenergic receptors leads to dilation of the coronary arteries.
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