rizatriptan

Ligand id: 51

Name: rizatriptan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 49.74
Molecular weight 269.16
XLogP 1.35
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of migraine.
Mechanism Of Action and Pharmacodynamic Effects
Selective agonist of 5-HT type 1B and 1D receptors. Stimulation of 5-HT1D receptors inhibits dural vasodilation and inflammation, while agonism of both receptor subtypes in the brainstem inhibits trigeminal nuclei cell excitability. Vascular 5-HT1B receptor agonism causes vasoconstriction of meningeal, dural, cerebral or pial vessels.
External links