Ligand id: 5225

Name: milrinone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 65.78
Molecular weight 211.07
XLogP 1.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits erythrocyte phosphodiesterase, leading to an increase in erthrocyte cAMP activity. This leads to a resistance to deformity in the erythrocyte membrane. Milronine also reduces plasma fibrinogen concentrations and increases fibrinolytic activity.
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