Ligand id: 5285

Name: vinpocetine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 34.47
Molecular weight 350.2
XLogP 5.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Vinpocetine is approved internationally, but use in the US is restricted to dietary supplements.
Vinpocetine is used to treat cerebrovascular disorders and age-related memory impairment. This is based on its reported ability to increase cerebral blood-flow [5] and produce a neuroprotective effect.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of phosphodiesterase (PDE) type-1 by vinpocetine is believed to underlie its blood-flow enhancing effect [1,6]. The compound's neuroprotective effect is thought to be due to its Inhibition of voltage-sensitive Na+ channels [4].