Ligand id: 5297

Name: zileuton

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: zileuton

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 94.8
Molecular weight 236.06
XLogP 1.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the prophylaxis and chronic treatment of asthma.
Mechanism Of Action and Pharmacodynamic Effects
Through its inhibition of 5-lipoxygenase, zileuton inhibits the formation of leukotrienes LTB4, LTC4, LTD4, and LTE4, which are formed from arachidonic acid in the reaction catalysed by this enzyme. An additional activity of zileuton is direct reduction of sebaceous lipids production [1].
External links