Ligand id: 535

Name: dobutamine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 4
Rotatable bonds 7
Topological polar surface area 72.72
Molecular weight 301.17
XLogP 3.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dobutamine is used to improve cardiac function in patients following either myocardial infarction or cardiac surgery.
Mechanism Of Action and Pharmacodynamic Effects
Dobutamine stimulates β1-adrenoceptors in the heart. The drug-induced effect is increased myocardial contractility and stroke volume which result in improved cardiac output.