sulindac

Ligand id: 5425

Name: sulindac

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 73.58
Molecular weight 356.09
XLogP 4.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
For acute relief or long term use in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder and acute gouty arthritis.
Mechanism Of Action and Pharmacodynamic Effects
Sulindac is believed to inhibit prostaglandin synthesis via the inhibition of both COX-1 and COX-2 leading to antiinflammatory effects.
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