Ligand id: 5443

Name: guanabenz

Abbreviated name: GBZ

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 76.76
Molecular weight 230.01
XLogP 2.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Guanabenz is used to treat hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Guanabenz is an α2-adrenoceptor agonist. Guanabenz-induced central α-adrenergic stimulation results in reduced sympathetic outflow to the heart, kidneys, and peripheral vasculature and to reduced systolic and diastolic blood pressure, and reduced heart beat rate.