practolol

Ligand id: 555

Name: practolol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 70.59
Molecular weight 266.16
XLogP 1.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the emergency treatment of cardiac arrhythmias. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Antagonist of beta-1 adrenoceptors in the heart and vascular smooth muscle, competing with the binding of adrenaline and noradrenaline and therefore inhibiting their effects, this has the outcome of decreasing heart rate, cardiac output and systolic and diastolic blood pressure.