Ligand id: 564

Name: propranolol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 41.49
Molecular weight 259.16
XLogP 4.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the prevention of migraine in adults. In 2014, the US FDA approved propranolol as a treatment for infantile hemangioma ( "strawberry" birthmarks).
Mechanism Of Action and Pharmacodynamic Effects
β1-adrenoceptor antagonist, which inhibits sympathetic stimulation leading to a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure and reflex orthostatic hypotension.
In infantile hemangioma propranolol action effectively starves the hemangioma of blood, which ultimately leads to its regression and disappearance.
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