Ligand id: 5775

Name: AZD2624

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 96.54
Molecular weight 459.16
XLogP 8.15
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
As AZD2624 the compound failed in a schizophrenia proof-of-principle study [3] (see NCT00686998). A trial of AZD4901 for Polycystic Ovary Syndrome was reported in 2016 [2] (see NCT01872078) As MLE4901 this compound has completed Phase 2 clinical trial for management of menopausal hot flushes [4]. MLE4901 was found to be safe and effective in this trial (see NCT02668185). A Phase 2 study for the treatment of polycystic ovary syndrome (PCOS) is underway (NCT02865915), Dose selection was determined as reported in [6].