treprostinil

Ligand id: 5820

Name: treprostinil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 86.99
Molecular weight 390.24
XLogP 4.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Treprostinil is a synthetic analogue of PGI2 (prostacyclin), used to treat pulmonary hypertension. In the EU treprostinil diethanolamine and treprostinil sodium have been granted orphan designation for the treatment of pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension and systemic sclerosis (treprostinil diethanolamine only).
Mechanism Of Action and Pharmacodynamic Effects
Causes vasodilation of pulmonary and systemic arterial bed and inhibition of platelet aggregation by activating the prostacyclin receptor (aka IP receptor, PTGIR).
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