losartan

Ligand id: 590

Name: losartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 92.51
Molecular weight 422.16
XLogP 7.25
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat complicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. Also used as a treatment for diabetic nephropathy.
Mechanism Of Action and Pharmacodynamic Effects
Losartan is a competitive inhibitor of the AT1 receptor, leading to reduced binding of angiotensin II. This leads to an inhibition of the effects mediated by angiotensin II, namely vasocontriction and aldosterone secretion therefore the activity of losartan leads to a decreased in blood pressure and vascular resistance.