Ligand id: 5936

Name: nintedanib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 94.22
Molecular weight 539.25
XLogP 4.97
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Nintedanib has been approved as a treatment for idiopathic pulmonary fibrosis. Click here to link to view additional trials registered with
Marketed formulations contain nintedanib esylate (PubChem CID 9809714).
Mechanism Of Action and Pharmacodynamic Effects
Nintedanib inhibits multiple angiogenic pathways, and appears to also inhibit pathways associated with the fibrotic scarring of the lung observed in idiopathic pulmonary fibrosis (IPF). In tumours inhibition of VEGF receptor (VEGFR), PDGFR and FGFR kinase activity reduces tumour angiogenesis/neo-vascularisation, thereby restricitng tumour expansion [2]. The mechanism in IPF is less clear. See [1] and [3] for further information.