zolmitriptan

Ligand id: 60

Name: zolmitriptan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 57.36
Molecular weight 287.16
XLogP 1.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Zolmitriptan is delivered as a nasal spray formulation..Originally approved to treat acute migraine in adults, with FDA approval for use in children between the ages of 12-17 following in 2015.
Mechanism Of Action and Pharmacodynamic Effects
The high affinity binding of zolmitriptan to 5-HT1B and 5-HT1D receptors causes constriction of the cranial blood vessels. Symptoms of migraine are believed to be caused by dilation of these blood vessels.
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