fosinoprilat

Ligand id: 6457

Name: fosinoprilat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 104.72
Molecular weight 435.22
XLogP 6.29
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The prodrug is administered to treat hypertension, as an adjunct in the management of congestive heart failure and to slow progression of renal disease.
Mechanism Of Action and Pharmacodynamic Effects
Fosinoprilat competes with angiotensisn I for binding to ACE thereby inhibiting its enzymatic conversion to angiotensin II. Reduced levels of angiotensin II leads to reduced blood pressure. However, we have been unable to find molecular data for this drug at the human target, to substantiate its MMOA.