zofenopril

Ligand id: 6462

Name: zofenopril

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 125.28
Molecular weight 429.11
XLogP 5.75
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension and coronary heart disease. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
The active form zofenoprilat acts an inhibitor of angiotensin converting enzyme (ACE). Inhibition of ACE acts on the renin-angiotensin-aldosterone system (RAAS) to relax blood vessels which leads to a reduction in blood pressure.