Ligand id: 6571

Name: moexipril

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 114.4
Molecular weight 498.24
XLogP 4.86
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Converted to the active metabolite moexiprilat, an inhibitor of angiotensin-converting enzyme. This inhibition prevents the conversion of angiotensin I to angiotensin II, thereby reducing the vasoconstriction and aldosterone secretion stimulated by angiotensin II. Also causes increased plasma renin activity.
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