Ligand id: 6591

Name: natalizumab

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Summary of Clinical Use
Used in the treatment of relapsing forms of multiple sclerosis, and in the management of Crohn's disease. However, natalizumab is not widely prescribed due to safety concerns around progressive multifocal leukoencephalopathy (PML).
Mechanism Of Action and Pharmacodynamic Effects
Binds to the α4-subunit of α4β1 and α4β7 integrins on leukocyte cell surfaces [1] which inhibits the adhesion of leukocytes to their counter-receptor, vascular cell adhesion molecule-1 (VCAM-1). This action limits T cell migration to inflamed tissue, thereby reducing active inflammation.
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