Ligand id: 6601

Name: bambuterol

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: bambuterol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 91.34
Molecular weight 367.21
XLogP 1.84
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Bambuterol is a long acting β-adrenoceptor agonist used as an anti-asthmatic. It is a prodrug of terbutaline.
Mechanism Of Action and Pharmacodynamic Effects
Stimulation of β-adrenergic receptors increases intracellular cyclic AMP levels and causes relaxation of bronchial smooth muscle and inhibits release of causative agents of allergic reaction, such as histamine, leukotriene and prostaglandin from surrounding cells, especially mast cells.