Ligand id: 6647

Name: entacapone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 127.7
Molecular weight 305.1
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to improve the efficiency of levodopa / carbidopa treatment in patients with Parkinson's disease.
Mechanism Of Action and Pharmacodynamic Effects
COMT is an enzyme that degrades catecholamines, including levodopa (dopamine precursor) used to treat Parkinson's disease (PD). By inhibiting COMT action, entacapone prolongs the bioavailability of levodopa in combination PD therapy.