methimazole

Ligand id: 6649

Name: methimazole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 56.62
Molecular weight 114.03
XLogP 0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits the action of the enzyme thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Also reduces CXCL10 levels producing and anti-inflammatory effect.