propylthiouracil

Ligand id: 6650

Name: propylthiouracil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 73.22
Molecular weight 170.05
XLogP 1.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of Grave's disease.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits thyroid peroxidase and thereby the conversion by this enzyme of iodide to iodine, and the incorporation of the iodine molecule onto the phenol rings to tyrosine found in thyroglobulin. As thryroglobulin is normally degraded to produce thyroxine and tri-iodothyronine, propylthiouracil inhibits the production of new thyroid hormones.
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