von Willebrand factor

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Ligands
von Willebrand factor (Human)

GtoPdb Ligand ID: 6755

Synonyms: Vonvendi® | vWF

von Willebrand factor is an approved drug (FDA (2015))

Compound class: Endogenous peptide in human, mouse or rat

Comment: Details of the structure of von Willebrand factor (vWF) are available in its UniProt record. The pre-pro peptide is 2813 amino acids, with residues 1-22 being the signal peptide, residues 23-763 forming von Willebrand antigen 2, and the remaining 2050 residues (764-2813) constituting vWF. The Uniprot record also provides details of mutations underlying defective vWF activity in the three subtypes of von Willebrand disease.

Species: Human

No information available.

No information available.

Summary of Clinical Use
A recombinant version of the protein (Vonvendi®) has been approved by the US FDA as the first recombinant vWF product licensed to be used on-demand for von Willebrand disease (VWD) patients suffering bleeding episodes. This approval replaces the need to use vWF concentrate, which was purified from human plasma.

Summary of Clinical Use

A recombinant version of the protein (Vonvendi®) has been approved by the US FDA as the first recombinant vWF product licensed to be used on-demand for von Willebrand disease (VWD) patients suffering bleeding episodes. This approval replaces the need to use vWF concentrate, which was purified from human plasma.