von Willebrand factor

Ligand id: 6755

Name: von Willebrand factor

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (FDA (2015))
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
VWF von Willebrand factor Human von Willebrand factor F8VWF
Synonyms
Vonvendi® | vWF
Database Links
CATH/Gene3D 3.40.50.410
DrugBank Target P04275 (Hs)
Ensembl Gene ENSG00000110799 (Hs)
Entrez Gene 7450 (Hs)
Human Protein Atlas ENSG00000110799 (Hs)
UniProtKB P04275 (Hs)
Wikipedia Von_Willebrand_factor
Comments
Details of the structure of von Willebrand factor (vWF) are available in its UniProt record. The pre-pro peptide is 2813 amino acids, with residues 1-22 being the signal peptide, residues 23-763 forming von Willebrand antigen 2, and the remaining 2050 residues (764-2813) constituting vWF. The Uniprot record also provides details of mutations underlying defective vWF activity in the three subtypes of von Willebrand disease.