acetazolamide

Ligand id: 6792

Name: acetazolamide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 151.66
Molecular weight 221.99
XLogP -1.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat certain types of glaucoma, epilepsy, or edema (fluid buildup) in combination with other medicines. Decreases fluid build-up/pressure in the eyeball (glaucoma) and acts as a diuretic in the kidneys, increasing fluid removel. Antiepileptic effect is believed to be due to inhibition of carbonic anhydrase in the brain which results in increased inhibition of transneuronal signal transduction, via increased chloride current.
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