Ligand id: 6795

Name: allopurinol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 53.16
Molecular weight 137.05
XLogP -0.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Primarily used to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. A fixed dose combination of allopurinol and the urate transporter inhibitor lesinurad (Duzallo®) was FDA approved in August 2017, for the treatment of gout that is not controlled by allopurinol alone.. Allopurinol sodium has been granted orphan designation by the EMA for the treatment of perinatal asphyxia.
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