etoposide

Ligand id: 6815

Name: etoposide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 160.83
Molecular weight 588.18
XLogP 0.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This compund is a topoisomerase inhibitor used as an anticancer agent, for cancers such as Kaposi's sarcoma, Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, nonlymphocytic leukemia, and glioblastoma multiforme. It is often given in combination with other drugs (such as bleomycin in treating testicular cancer). It is also sometimes used in a conditioning regimen prior to a bone marrow or blood stem cell transplant
Mechanism Of Action and Pharmacodynamic Effects
Inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, leading to the accumulation of DNA breaks which prevent the cell from entering mitotic cell division and subsequent cell death.
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