fondaparinux

Ligand id: 6819

Name: fondaparinux

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 52
Hydrogen bond donors 19
Rotatable bonds 30
Topological polar surface area 872.52
Molecular weight 1506.95
XLogP -18.67
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used for the prevention of venous thrombosis in various at-risk patient groups.
Mechanism Of Action and Pharmacodynamic Effects
A synthetic pentasaccharide factor Xa inhibitor: Binds selectively to ATIII potentiating its neutralizing action on Factor Xa. Neutralization of Factor Xa decreases the conversion of prothrombin to thrombin, and the conversion of fibrinogen to fibrin (ie decreases the potential for clot formation)