nateglinide

Ligand id: 6833

Name: nateglinide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 66.4
Molecular weight 317.2
XLogP 6.38
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
An oral antihyperglycemic agent used to treat non-insulin-dependent diabetes mellitus.
Mechanism Of Action and Pharmacodynamic Effects
An amino acid derivative, that unlike the sulfonylureas is dependent on the presence of functioning β cells and glucose. May act by potentiating the effect of extracellular glucose on ATP-sensitive potassium channels on the β cell surface.
External links