Ligand id: 6881

Name: tocilizumab

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Summary of Clinical Use
Approved as a treatment for rheumatoid arthritis and systemic and polyarticular juvenile idiopathic arthritis. Tocilizumab may be used off-label to manage severe or life-threatening cytokine release syndrome.
In May 2017 tocilizumab became the first FDA approved drug for the treatment of adults with giant cell arteritis.
Phase 3 clinical trials for immune conditions including RA, ankylosing spondylitis, hand osteoarthritis, systemic sclerosis and primary Sjögren's syndrome (pSS) are ongoing.
Mechanism Of Action and Pharmacodynamic Effects
Binds to soluble and membrane-bound IL-6 receptors to inhibit IL-6 signalling via these receptors, thereby reducing the effect of the elevated/deregulated circulating IL-6 which is a hallmark of the targeted chronic autoimmume diseases.
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