muromonab-CD3

Ligand id: 6889

Name: muromonab-CD3

No information available.
Summary of Clinical Use
Used to prevent renal, cardiac and hepatic allograft rejection. Due to reduced demand and use in the US, the manufacturer has withdrawn muromonab-CD3 from the US market.
Mechanism Of Action and Pharmacodynamic Effects
The antibody binds to the T-cell surface glycoprotein CD3 and appears to kill these cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
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