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Synonyms: L04AA02 | OKT-3 | Orthoclone Okt3®
muromonab-CD3 is an approved drug (FDA (1992))
Compound class:
Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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| No information available. |
Summary of Clinical Use  |
| Used to prevent renal, cardiac and hepatic allograft rejection. Due to reduced demand and use in the US, the manufacturer has withdrawn muromonab-CD3 from the US market. |
| Mechanism Of Action and Pharmacodynamic Effects |
| The antibody binds to the T-cell surface glycoprotein CD3 and appears to kill these cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity. |
| External links |
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For extended ADME data see the following: Drugs.com |
