omalizumab

Ligand id: 6890

Name: omalizumab

No information available.
Summary of Clinical Use
Used to treat moderate to severe IgE-mediated (i.e. allergy triggered) persistent asthma (US) or severe asthma (EU) [2], in adults and children over 12 years old, inadequately controlled by inhaled corticosteroid treatment. In 2014 the US FDA approved use of this drug for the treatment of chronic idiopathic urticaria (CIU, a.k.a. chronic spontaneous urticaria) which is unresponsive to treatment with anti-histamine H1 receptor drugs.
In July 2016, the FDA expanded asthma approval to include children six to 11 years of age, as indicated previously for those 12 years-adult.
Mechanism Of Action and Pharmacodynamic Effects
Binds to IgE antibodies thereby preventing their binding to, and activation of mast cells and basophils. This action leads to reduced release of mediators of the allergic response.
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