Ligand id: 6960

Name: anisindione

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 43.37
Molecular weight 252.08
XLogP 3.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat venous thrombosis and pulmonary embolism and used with other drugs to treat occlusion in coronary arteries.
Mechanism Of Action and Pharmacodynamic Effects
Anisindione prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting vitamin K-dependent gamma-carboxylase, the enzyme responsible for vitamin K-mediated gamma-carboxylation of precursor proteins.