Ligand id: 6975

Name: vismodegib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 84.51
Molecular weight 420.01
XLogP 4.45
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Vismodegib is approved for the treatment of basal-cell carcinoma.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of SMO prevents activation of the transcription factors GLI1 and GLI2, and tumor mediating genes within the hedgehog pathway are prevented from being expressed.
External links