dimethyl fumarate

Ligand id: 7045

Name: dimethyl fumarate

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: dimethyl fumarate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 52.6
Molecular weight 144.04
XLogP 0.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Dimethylf fumarate is an anti-inflammatory drug used to treat patients with relapsing multiple sclerosis.
Mechanism Of Action and Pharmacodynamic Effects
Although the exact mechanism of action of dimethyl fumarate is poorly understood, it is believed that the benefits of using this drug are likely to be due to the anti-inflammatory and cytoprotective actions of its active metabolite. This activity is potentially due to inhibition of KEAP1 (Kelch-like ECH-associated protein 1 inhibitor) regulation of Nrf2 signalling of the antioxidant response when cells experience oxidative stress [1].