perampanel

Ligand id: 7050

Name: perampanel

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 56.99
Molecular weight 349.12
XLogP 6.46
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Perampanel is used to treat seizures in adults and children (>12 yrs). In June 2015, the US FDA expanded approval to include the treatment of patients (≥12 years old) suffering from primary generalized tonic-clonic (PGTC) seizures.
Fycompa® is available in tablet form and as a bioequivalent oral suspension (Fycompa® CIII Oral Suspension, FDA approved in May 2016).
Mechanism Of Action and Pharmacodynamic Effects
Perampanel appears to decrease neuronal excitation by ihibiting the ionic glutamate (AMPA) receptors (GRIA1-4), although downstream mechanisms causing its anti-seizure action remain undetermined.
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