ethinylestradiol

Ligand id: 7071

Name: ethinylestradiol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 40.46
Molecular weight 296.18
XLogP 4.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The single compound may be used to control hot flushes associated with the menopause, or to treat female hypogonadism. This compound may also be used in the palliative care of patients with advanced prostate cancer and breast cancer. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
This drug mimics the agonist action of the endogenous hormone at the estrogen receptor. Circulating estrogen negatively feeds-back to reduce circulating levels of FSH and LH.