Ligand id: 7083

Name: idarubicin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 176.61
Molecular weight 497.17
XLogP -0.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Idarubicin is used to treat acute myeloid leukemia (AML)
Mechanism Of Action and Pharmacodynamic Effects
Idarubicin disrupts DNA function and replication, by directly intercalating into the DNA structure, and by inhibiting the progression of topoisomerase II, an enzyme essential for transcription and DNA replication. This DNA damage leads to apoptotic cell death.
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