methylprednisolone

Ligand id: 7088

Name: methylprednisolone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 374.21
XLogP 1.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Methylprednisolone is used to treat numerous inflammatory conditions including arthritis, lupus, psoriasis, ulcerative colitis and allergic disorders. The drug is also used to treat glucocorticoid-responsive conditions of the skin, eyes, lungs, stomach, nervous system and blood cells, and some endocrine conditions.
Mechanism Of Action and Pharmacodynamic Effects
As an agonist of the glucocorticoid receptor, methylprednisolone modulates expression of genes containing the glucocorticoid response element (GRE). Although complex, the response appears to include inhibition of the biosynthesis of pro-inflammatory prostaglandins and leukotrienes.
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