neomycin

Ligand id: 709

Name: neomycin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 19
Hydrogen bond donors 13
Rotatable bonds 9
Topological polar surface area 353.11
Molecular weight 614.31
XLogP -6.91
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used topically in the treatment of eye infections, otitis externa, treatment or prevention of bacterial infections in skin lesions and in the prevention of bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. Also used orally to treat hepatic encephalopathy.
Mechanism Of Action and Pharmacodynamic Effects
Neomycin binds to 30S-subunit proteins and 16S rRNA. This leads to misreading of mRNA which in turn leads to the insertion of incorrect amino acids into the polypeptide which leads to the formation of nonfunctional or toxic peptides and breakup of polysomes into nonfunctional monosomes.
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