pentoxifylline

Ligand id: 7095

Name: pentoxifylline

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: pentoxifylline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 75.51
Molecular weight 278.14
XLogP -0.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat intermittent claudication associated with peripheral vascular disease.
Mechanism Of Action and Pharmacodynamic Effects
The action of this drug in improving circulation is likely related to its ability to increase erythrocyte felxibility, meaning that the red blood cells can flow more easily through occluded peripheral vessels, thereby reducing clot-formed blockages [5]. The drug also inhibits phosphodiesterases [1] leading to increased cAMP and downstream inhibition of inflammatory mediators. The drug's antagonism of type 2 adrenoceptors may also be related to its anti-inflammatory action [3-4]. See the DrugBank link for further details.
External links