topotecan

Ligand id: 7101

Name: topotecan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 103.2
Molecular weight 421.16
XLogP 0.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Topotecan is a antineoplastic/chemotherapeutic agent used to treat metastatic ovarian cancer, relapsed or advanced cervical cancer (with cisplatin) and relapsed small cell lung cancer.
Mechanism Of Action and Pharmacodynamic Effects
Topotecan works in an identical manner to camptothecin. It inhibits the topoisomerase I enzyme (TOP1). This leads to breaks in the DNA strand and the DNA damage targets the cell to the apoptotic pathway.
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