Ligand id: 7170

Name: doxazosin

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View more information in the IUPHAR Pharmacology Education Project: doxazosin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 96.35
Molecular weight 451.19
XLogP 1.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat hypertension and to improve urination in patients with benign prostatic hyperplasia.
Mechanism Of Action and Pharmacodynamic Effects
As an antagonist of α1-adrenoceptors, doxazosin treatment causes smooth muscle relaxation in the peripheral vasculature and prostate gland by preventing the normal vasoconstriction response to catecholamines. See the DrugBank link for further details.
External links