hydroxyzine

Ligand id: 7199

Name: hydroxyzine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 35.94
Molecular weight 374.18
XLogP 4.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The sedative action of hydroxyzine is used to treat anxiety and tension and is combined with other medications in anesthesia. Hydroxyzine may also be used to control nausea and vomiting and be used as an antihistamine to control pruritic symptoms.
Mechanism Of Action and Pharmacodynamic Effects
Hydroxyzine's predominant mechanism of action is as a potent H1 receptor inverse agonist. Hydroxyzine acts to block the action of endogenous histamine at the histamine H1 receptor. The sedative action of the drug may be due to central anticholinergic activity, but this is less clearly understood.
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