inamrinone

Ligand id: 7202

Name: inamrinone

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: inamrinone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 72.03
Molecular weight 187.07
XLogP 0.9
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat congestive heart failure.
Mechanism Of Action and Pharmacodynamic Effects
Inamrinone increases cAMP and cGMP levels by inhibiting type 3 phosphodiesterases (PDE3A and PDE3B). This increases calcium ion entry into cardiac muscle cells, and increases the force of cardiac contraction (the inotropic effect).
External links